What does "come up" mean?

For a problem to arise When an issue or difficulty presents itself unexpectedly.

How do you use "come up" in a sentence?

Something came up at work. Problems always come up at the worst time. If anything comes up, let me know.

Phrasal Verb BritishAmericanAustralian ★★★★★ Very Common Neutral

Meaning: For a problem to arise

（问题）出现、发生

Surgir (un problema)

（問題が）発生する、持ち上がる

(문제가) 발생하다, 생기다

When an issue or difficulty presents itself unexpectedly.

问题或困难意外出现时。

Cuando un problema o dificultad se presenta inesperadamente.

問題や困難が予期せず現れること。

예기치 않게 문제나 어려움이 나타나다.

Base verb: come

Particle: up

Separable: No — the verb and particle stay together

Something came up at work.
工作上有事
Surgió algo en el trabajo
仕事で何か用事ができた
직장에서 일이 생겼다.
Problems always come up at the worst time.
问题总是在最糟糕的时候出现
Los problemas siempre surgen en el peor momento
問題はいつも最悪のタイミングで起きる
문제는 항상 최악의 타이밍에 생긴다.
If anything comes up, let me know.
如果有什么事，告诉我
Si surge algo, avisadme
何かあったら教えて
무슨 일이 생기면 알려 줘.

Context: problems, unexpected, issues

Tone: concerned

From something coming up into view or awareness.

Era: Modern

Generation: All ages

Social background: Universal